British Air Force Typhoon fighter aircraft have operated alongside France's air force in a combined operation targeting an hidden munitions depot in Syrian territory used by the IS group, according to the British defence ministry.
The site, pinpointed through reconnaissance, was assessed as containing munitions and bombs, the announcement noted, and was positioned in mountainous terrain just north of the historic site of Palmyra in central Syria.
"Our fighter planes employed precision-guided Paveway IV munitions to target a series of entry passages leading to the site... initial indications suggest the objective was successfully hit," the MoD said.
There was no sign of any harm to civilians in the strike late on Saturday and all the aircraft returned to base without incident, the MoD added.
The British jets were supported by a Voyager refuelling tanker.
The Islamic State group - also known as ISIS - enforced jihadist rule over significant areas in both Syria and Iraq prior to its 2019 collapse.
"This strike underscores the UK's leading role, and resolve to work closely with our allies, to eradicate any re-emergence of the terrorist group and their violent and radical beliefs in the region," UK Defence Secretary the minister remarked.
British military aircraft have performed surveillance missions over Syria to "forestall any attempted comeback" of IS after its defeat at the climactic battle in Baghuz in the year 2019, the ministry said.
"I want to thank every member of the UK armed forces involved in this mission for their skill and their courage," he said. "Including them were a great many British personnel stationed over the holidays. This mission, to eliminate militants who threaten our safety, demonstrates how UK forces are ready to step up, continuously, protecting the UK domestically and influential overseas."
In December, the US military executed what it described as a "major assault" targeting Islamic State objectives in the country, following an attack resulted in the deaths of two US troops and a civilian linguist in the Palmyra area.
The U.N. estimates Daesh still maintains roughly 5-7 thousand militants in both countries.